Description

How Supplied:

Each 5 ml syrup contains 200 mg Guaifenesin, 30 mg Dextromethorphan Hydrobromide, 10 mg Phenylephrine Hydrochloride. 60 ml syrup in a bottle.

Category

Expectorant, Antitussive, Decongestant

Mechanism of Action

Guaifenesin is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi.

Dextromethorphan acts on cough center in medulla; decreases sensitivity of cough receptors and interrupts cough impulse transmission.

Phenylephrine, which is a nasal decongestant. It unblocks a stuffy nose and helps the patient to breathe more easily by reducing the swelling in the nasal passages.

Pharmacokinetics

Absorption

Guaifenesin is rapidly absorbed after oral administration.

Dextromethorphan is well absorbed from the gut following oral administration.

Phenylephrine hydrochloride is irregularly absorbed from the gastrointestinal tract, and also it undergoes rapid distribution into peripheral tissues.

Distribution

No information is available on the distribution of guaifenesin and phenylephrine in humans.

Due to extensive pre-systemic metabolism by the liver, detailed analysis of the distribution of orally administered dextromethorphan is not possible.

Elimination

Renal, as inactive metabolites.

Dosage and Administration

Usual adult and adolescent dose:

Use exactly as prescribed by your doctor. Cold or cough medicine is only for short-term use until your symptoms clear up.

Usual dose for >12 years 5ml every 6-8 hours, up to 20 ml/day.

Usual pediatric dose:

Use exactly as prescribed by your doctor. Cold or cough medicine is only for short-term use until your symptoms clear up.

Children 6 to 12: 2.5 ml every 6-8 hours, up to 10 ml/day

Pregnancy and breast feeding

Ask a health professional before use.

Side Effects:

Adverse Reactions Frequency not defined. The following adverse events have been reported with the combination product:

Cardiovascular: Circulatory shock, palpitations, tachycardia

Central nervous system: Anxiety, central nervous system depression, convulsions, dizziness, drowsiness, excitability, fear, hallucination, headache, insomnia, irritability, nervousness

Gastrointestinal: Nausea, vomiting

Neuromuscular & skeletal: Tremor, weakness

Respiratory: Dyspnea

Warnings/Precautions:

Don’t use if you have hypersensitivity to Guaifenesin, Dextromethorphan, Phenylephrine or any other ingredients in formulation.

Use with caution in:

• Cardiovascular disease
• Diabetes mellitus
• Increased intraocular pressure/glaucoma
• Prostatic hyperplasia/urinary obstruction
• Thyroid dysfunction

Drug interactions:

Before using this syrup, consult with your doctor or pharmacist if you take another medication.

Storage:

Store below 30˚c, in a tight container. Protect from freezing.

Keep out of sight and reach of children.